2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

Base Information

Chemical Name:2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate
CAS No.:1217340-49-2
Molecular Formula:C₁₇H₁₀F₄N₂O₇S
Molecular Weight:462.335
Hs Code.:

Synonyms:2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

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Chemical Property of 2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

There total 5 articles about 2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1217340-49-2
2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3: sodium hydroxide; water / ethanol / 70 °C

4: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

: 1217340-49-2
2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid / chloroform / 0.17 h / 20 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4: sodium hydroxide; water / ethanol / 70 °C

5: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

With water; nitric acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1217340-48-1
2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylic acid

: 1217340-49-2
2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-nitrobenzofuran-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: sodium hydroxide; water / ethanol / 70 °C

3: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;