5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

Base Information

Chemical Name:5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde
CAS No.:1449692-04-9
Molecular Formula:C₂₀H₁₈ClNO
Molecular Weight:323.822
Hs Code.:

Synonyms:5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

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Chemical Property of 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

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Technology Process of 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

There total 14 articles about 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1449692-03-8
[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

: 1449692-04-9
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 12h; Reflux;
DOI:10.1016/j.ejmech.2015.06.057

Reference yield:

: 1449691-99-9
N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide

: 1449692-04-9
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.12 h / 3 - 8 °C

2.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane; sodium thiosulfate pentahydrate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium thiosulfate pentahydrate; sodium hydride; Dess-Martin periodane; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400070u

Reference yield:

: [(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)-methyl]-isocyanide

: 1449692-04-9
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

4.1: Dess-Martin periodane; sodium thiosulfate pentahydrate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium thiosulfate pentahydrate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400070u