[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

Base Information

Chemical Name:[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol
CAS No.:1449692-03-8
Molecular Formula:C₂₀H₂₀ClNO
Molecular Weight:325.838
Hs Code.:

Synonyms:[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

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Technology Process of [5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

There total 13 articles about [5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1480377-53-4
5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

: 1449692-03-8
[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.06.057

Reference yield:

: 1449692-02-7
5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 1449692-03-8
[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4.5h; Inert atmosphere;
DOI:10.1021/jm400070u

Reference yield:

: 1449691-99-9
N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide

: 1449692-03-8
[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.12 h / 3 - 8 °C

2.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; trichlorophosphate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400070u