dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

Base Information

Chemical Name:dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate
CAS No.:1449692-07-2
Molecular Formula:C₃₃H₄₃ClNO₄P
Molecular Weight:584.135
Hs Code.:

dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

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Chemical Property of dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

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Technology Process of dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

There total 11 articles about dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1449692-04-9
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde

: 1449692-06-1
dimethyl ([(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-methyl)phosphonate

: 1449692-07-2
dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

: 1449691-92-2
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-3-[(E)-2-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethenyl]-1H-pyrrole

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; acetone; for 1h; Inert atmosphere;
DOI:10.1021/jm400070u

Reference yield:

: 101349-71-7
4-Chloro-3-methylbenzaldehyde

: 1449692-07-2
dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

: 1449691-92-2
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-3-[(E)-2-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloro-trimethyl-silane / toluene; acetonitrile / 5 h / 50 °C / Inert atmosphere

1.2: 5 h / 20 - 50 °C / Inert atmosphere

2.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.12 h / 3 - 8 °C

3.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

6.1: Dess-Martin periodane; sodium thiosulfate pentahydrate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; acetone; hexane / 1 h / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; sodium thiosulfate pentahydrate; sodium hydride; Dess-Martin periodane; trichlorophosphate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;
DOI:10.1021/jm400070u

Reference yield:

: 1449691-99-9
N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide

: 1449692-07-2
dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate

: 1449691-92-2
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-3-[(E)-2-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.12 h / 3 - 8 °C

2.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane; sodium thiosulfate pentahydrate / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; acetone; hexane / 1 h / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; sodium thiosulfate pentahydrate; sodium hydride; Dess-Martin periodane; trichlorophosphate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/jm400070u