tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

Base Information

Chemical Name:tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate
CAS No.:1361990-92-2
Molecular Formula:C₃₄H₄₆N₆O₄
Molecular Weight:602.777
Hs Code.:

tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

Synonyms:tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

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Chemical Property of tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

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Technology Process of tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

There total 10 articles about tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 827614-68-6
N-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1263425-52-0
tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

: 1361990-92-2
tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; at 130 ℃; for 0.166667h; microwave reaction;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1361990-92-2
tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 6 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 20 °C

2.2: 0.08 h / 120 °C / microwave reaction

3.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 0.17 h / 130 °C / microwave reaction

With sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; chloroform; water; 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil;

Reference yield:

: 180516-87-4
4-carboxyphenylboronic acid pinacol ester

: 1361990-92-2
tert-butyl cyclohexylmethyl(3-(4-(cyclopropylcarbonyl)phenyl)-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 0.17 h / 130 °C / microwave reaction

With sodium hydrogencarbonate; triethylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; N,N-dimethyl-formamide;