tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

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Chemical Name:tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate
CAS No.:1263425-52-0
Molecular Formula:C₂₄H₃₆BrN₅O₃
Molecular Weight:522.486
Hs Code.:

Synonyms:tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

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Chemical Property of tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

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Technology Process of tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

There total 8 articles about tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 130290-79-8
4-tetrahydropyranmethylamine

: 1263425-51-9
tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

: 1263425-52-0
tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 6h;

4-tetrahydropyranmethylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.0833333h; microwave reaction;

Reference yield:

: 887475-71-0
6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine

: 1263425-52-0
tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2,4-dichlorophenoxyacetic acid dimethylamine / 5 h / 120 °C

2.1: N-Bromosuccinimide / ethanol / 4 h / 20 °C

3.1: chloro-trimethyl-silane / 36 h / 80 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 0.33 h / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

6.1: potassium iodide; sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 6 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 20 °C

7.2: 0.08 h / 120 °C / microwave reaction

With N-Bromosuccinimide; chloro-trimethyl-silane; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium iodide; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; chloroform; 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil;

Reference yield:

: 887475-94-7
8-(methylthio)imidazo[1,2-a]pyrazine-6-carbonitrile

: 1263425-52-0
tert-butyl 3-bromo-8-((tetrahydro-2H-pyran-4-yl)methylamino)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / ethanol / 4 h / 20 °C

2.1: chloro-trimethyl-silane / 36 h / 80 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 0.33 h / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

5.1: potassium iodide; sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 6 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 20 °C

6.2: 0.08 h / 120 °C / microwave reaction

With N-Bromosuccinimide; chloro-trimethyl-silane; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium iodide; lithium hydroxide; In tetrahydrofuran; ethanol; chloroform; 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil;