1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane

Base Information

• Chemical Name: 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane
• CAS No.: 115256-44-5
• Molecular Formula: C₁₈H₂₃N₃O₅S
• Molecular Weight: 393.464

Synonyms:1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane

Chemical Property of 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane

Chemical Property:

• Boiling Point: 567.8±60.0 °C(Predicted)
• Density: 1.312±0.06 g/cm3(Predicted)

Purity/Quality:

N''-Desaminomethylsulfonyl-N''-nitrylDofetilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N''-Desaminomethylsulfonyl-N''-nitryl Dofetilide is an impurity of Dofetilide (D525700), a potassium channel blocker.

Technology Process of 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane

There total 4 articles about 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide (767618-90-6) → 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane (115256-44-5)

Guidance literature:

With formic acid; Heating;

DOI:10.1016/S0960-894X(00)00412-1

Reference yield:

2-{4-[(methylsulfonyl)-amino]-phenoxy}-ethyl chloride + N-methyl-N-[2-(4-nitro-phenyl)-ethyl]-amine (85176-37-0) → 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane (115256-44-5)

Guidance literature:

With sodium iodide; sodium hydrogencarbonate; In acetonitrile;

Reference yield:

p-nitrophenethylamine hydrobromide (69447-84-3) → 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane (115256-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.5 percent / K₂CO₃ / acetonitrile / Heating

2: 87.2 percent / HCO₂H / Heating

With formic acid; potassium carbonate; In acetonitrile; 1: Alkylation / 2: Methylation;

DOI:10.1016/S0960-894X(00)00412-1

upstream raw materials:

formaldehyd

N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide

p-nitrophenethylamine hydrobromide

N-methyl-N-[2-(4-nitro-phenyl)-ethyl]-amine

Downstream raw materials:

dofetilide

1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-aminophenethyl)amino]ethane

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