N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide

Base Information

• Chemical Name: N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide
• CAS No.: 1299482-57-7
• Molecular Formula: C₂₂H₁₆F₆N₂O₃
• Molecular Weight: 470.371

Synonyms:N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide

Chemical Property of N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide

Chemical Property:

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Technology Process of N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide

There total 5 articles about N₆-cyclopropyl-N₂-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid (1299483-20-7) + Cyclopropylamine (765-30-0) → N6-cyclopropyl-N2-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide (1299482-57-7)

Guidance literature:

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

4-formyl-3-hydroxybenzoic acid (619-12-5) → N6-cyclopropyl-N2-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide (1299482-57-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1.5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3.1: sodium hydroxide / ethanol / 2 h / Reflux

3.2: Cooling with ice

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 4-formyl-3-hydroxybenzoate (1017794-26-1) → N6-cyclopropyl-N2-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1-benzofuran-2,6-dicarboxamide (1299482-57-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

2.2: Cooling with ice

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1-benzofuran-6-carboxylic acid

Cyclopropylamine

4-formyl-3-hydroxybenzoic acid

tert-butyl 4-formyl-3-hydroxybenzoate

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