(5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine

Base Information

• Chemical Name: (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine
• CAS No.: 165524-37-8
• Molecular Formula: C₃₂H₃₀N₆O₆S₂
• Molecular Weight: 658.759

Synonyms:(5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine

Chemical Property of (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine

Chemical Property:

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Technology Process of (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine

There total 3 articles about (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N⁶-benzoyl-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-benzoyl-2',3'-isopropylidene-5'-carboxylic acid-5'-deoxy-adenosine (119750-97-9) → (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N6-benzoyl-adenine (165524-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tributylphosphine / CH₂Cl₂ / 1 h / Ambient temperature

2: CH₂Cl₂ / 0.5 h / 10 - 15 °C / Irradiation

With tributylphosphine; In dichloromethane;

DOI:10.1016/S0040-4020(01)88249-1

Reference yield:

PVS (5535-48-8) + (3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester (119750-98-0) → (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N6-benzoyl-adenine (165524-37-8)

Guidance literature:

In dichloromethane; at 10 - 15 ℃; for 0.5h; Yield given; Irradiation;

DOI:10.1016/S0040-4020(01)88249-1

Reference yield:

PVS (5535-48-8) + 2-mercaptopyridine-1-oxide sodium salt (3811-73-2) + N6-benzoyl-2',3'-isopropylidene-5'-carboxylic acid-5'-deoxy-adenosine (119750-97-9) → (5',6'-dideoxy-2',3'-isopropylidene-6'-phenylsulphonyl-6'-(2'-thiopyridyl)-β-D-ribo-5'-ene-hexofuranosyl)-9-N6-benzoyl-adenine (165524-37-8)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction;

DOI:10.1016/S0957-4166(00)86288-6

upstream raw materials:

PVS

(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

2-mercaptopyridine-1-oxide sodium salt

N⁶-benzoyl-2',3'-isopropylidene-5'-carboxylic acid-5'-deoxy-adenosine

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