2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Base Information

Chemical Name:2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine
CAS No.:497070-22-1
Molecular Formula:C₄₃H₅₉N₅O₇Si₂
Molecular Weight:814.142
Hs Code.:

Synonyms:2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

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Chemical Property of 2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

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Technology Process of 2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

There total 7 articles about 2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 497070-21-0
5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

: 497070-22-1
2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: With sodium hydroxide; In pyridine; water; at 20 ℃; for 0.166667h;
DOI:10.1002/1522-2675(200209)85:9<2930::AID-HLCA2930>3.0.CO;2-2

Reference yield:

: 9-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl]-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

: 497070-22-1
2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: With ammonium hydroxide; In pyridine; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2004.07.021

Reference yield:

: 2-Amino-9-[(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

: 497070-22-1
2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 20 °C

2: aqueous NH₃ / pyridine / 2 h / 20 °C

With ammonium hydroxide; In pyridine;
DOI:10.1016/j.bmc.2004.07.021