5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Base Information

Chemical Name:5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine
CAS No.:497070-21-0
Molecular Formula:C₄₅H₆₁N₅O₈Si₂
Molecular Weight:856.179
Hs Code.:

Synonyms:5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

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Chemical Property of 5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

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Technology Process of 5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

There total 1 articles about 5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 98151-64-5
5'-O-acetyl-2-N-(4,4'-dimethoxytrityl)guanosine

: 497070-21-0
5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h;
DOI:10.1002/1522-2675(200209)85:9<2930::AID-HLCA2930>3.0.CO;2-2

Reference yield: 83.0%

: 497070-21-0
5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

: 497070-22-1
2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

Guidance literature:: With sodium hydroxide; In pyridine; water; at 20 ℃; for 0.166667h;
DOI:10.1002/1522-2675(200209)85:9<2930::AID-HLCA2930>3.0.CO;2-2

Reference yield:

: 497070-21-0
5'-O-acetyl-2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine

: triethylammonium 2',3'-O-bis[(tert-butyl)dimethylsilyl]-2-N-(4,4'-dimethoxytrityl)guanosine 5'-O-phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / NaOH / H₂O; pyridine / 0.17 h / 20 °C

2.1: diphenyl phosphonate / pyridine / 2 h / 20 °C

2.2: 90 percent / H₂O; pyridine / 0.5 h / 20 °C

With sodium hydroxide; diphenyl hydrogen phosphite; In pyridine; water;
DOI:10.1002/1522-2675(200209)85:9<2930::AID-HLCA2930>3.0.CO;2-2