5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Base Information

Chemical Name:5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione
CAS No.:1350440-48-0
Molecular Formula:C₄₆H₄₈ClN₉O₆S₂
Molecular Weight:922.529
Hs Code.:

5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Synonyms:5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

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Chemical Property of 5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

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Technology Process of 5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

There total 4 articles about 5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350440-45-7
2-butyl-4-chloro-5-mercaptomethyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350440-48-0
5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; potassium carbonate / N,N-dimethyl-formamide; mineral oil / 7.75 h / 20 - 70 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C

2.2: 24 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 124751-00-4
2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol

: 1350440-48-0
5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

1.2: 4 h / 20 °C

2.1: 1,4-dithio-erythritol; morpholine / dichloromethane / 72 h / 20 °C

3.1: sodium hydride; potassium carbonate / N,N-dimethyl-formamide; mineral oil / 7.75 h / 20 - 70 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C

4.2: 24 h / 50 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

With morpholine; 1,4-dithio-erythritol; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350440-46-8
5-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthiomethyl)-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350440-48-0
5-(4-{4-(4-chloro-2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio)-2-(N-t-butoxycarbonyl-N-methylamino)phenylaminocarbonylmethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C

1.2: 24 h / 50 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;