5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Base Information

Chemical Name:5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole
CAS No.:1350440-44-6
Molecular Formula:C₄₃H₃₉ClN₆OS
Molecular Weight:723.341
Hs Code.:

Synonyms:5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

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Chemical Property of 5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

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Technology Process of 5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

There total 1 articles about 5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124751-00-4
2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol

: 10387-40-3
potassium thioacetate

: 1350440-44-6
5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Guidance literature:: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

potassium thioacetate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1350440-44-6
5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350440-45-7
2-butyl-4-chloro-5-mercaptomethyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Guidance literature:: With morpholine; 1,4-dithio-erythritol; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1350440-44-6
5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 5-(4-{6-[2-butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-ylmethylthio]-1-methyl-1H-benzimidazol-2-ylmethoxy}benzyl)thiazolidine-2,4-dione hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dithio-erythritol; morpholine / dichloromethane / 72 h / 20 °C

2.1: sodium hydride; potassium carbonate / N,N-dimethyl-formamide; mineral oil / 7.75 h / 20 - 70 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C

3.2: 24 h / 50 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 7 h / 80 °C

With morpholine; hydrogenchloride; 1,4-dithio-erythritol; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;