Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

Base Information

Chemical Name:Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester
CAS No.:1055031-30-5
Molecular Formula:C₅₄H₆₂O₁₀Si
Molecular Weight:899.166
Hs Code.:

Synonyms:Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

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Chemical Property of Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

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Technology Process of Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

There total 10 articles about Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 75-36-5
acetyl chloride

: 4-[(2R,3S,4S)-3-Benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenol

: 1055031-30-5
Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)74079-2

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1055031-30-5
Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / (i-Pr)2NEt / 22 h / 25 °C

2: 92 percent / (n-Bu)4NF / 0.5 h / 25 °C

3: 99 percent / Et₃N, DMAP / CH₂Cl₂

With dmap; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)74079-2

Reference yield:

: 152401-13-3
(4-bromo-2,6-dimethoxyphenoxy)(tert-butyl)dimethylsilane

: 1055031-30-5
Acetic acid 4-[(2R,3S,4S)-3-benzyloxy-2,4-bis-benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-2,6-dimethoxy-phenyl ester

Guidance literature:: Multi-step reaction with 9 steps

2: Et₃N

3: 98 percent / LiAlH₄

4: 86 percent / 20percent aq. HNO₃ / 1,2-dimethoxy-ethane / 3.5 h / 50 °C

5: 93 percent / NaBH₃CN, CF₃CO₂H / ethanol; tetrahydrofuran / 25 °C

6: 87 percent / imidazole / dimethylformamide; CH₂Cl₂ / -42 °C

7: 85 percent / (i-Pr)2NEt / 22 h / 25 °C

8: 92 percent / (n-Bu)4NF / 0.5 h / 25 °C

9: 99 percent / Et₃N, DMAP / CH₂Cl₂

With 1H-imidazole; dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; nitric acid; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74079-2