4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Base Information

Chemical Name:4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole
CAS No.:1258604-42-0
Molecular Formula:C₂₅H₃₀N₄O₃S
Molecular Weight:466.604
Hs Code.:

Synonyms:4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Suppliers and Price of 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

There total 5 articles about 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258604-31-7
4-(2,2-dimethyl-1,3-dioxan-5-yl)phenol

: 1258604-45-3
(2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methyl methanesulfonate

: 1258604-42-0
4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 56441-69-1
2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

: 1258604-42-0
4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / THF (tetrahydrofuran) / 19 h / 0 - 30 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

2.2: Cooling with ice

3.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With sodium tetrahydroborate; ammonium formate; sodium hydride; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 24220-48-2
diethyl 2-(4'-benzyloxyphenyl)malonate

: 1258604-42-0
4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With sodium tetrahydroborate; ammonium formate; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; toluene;