2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

Base Information

Chemical Name:2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol
CAS No.:1258604-43-1
Molecular Formula:C₂₂H₂₆N₄O₃S
Molecular Weight:426.539
Hs Code.:

Synonyms:2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

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Chemical Property of 2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

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Technology Process of 2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

There total 6 articles about 2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258604-42-0
4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole

: 1258604-43-1
2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

Guidance literature:: With hydrogenchloride; In water; acetone; at 27 ℃; for 12h;

Reference yield:

: 56441-69-1
2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

: 1258604-43-1
2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / THF (tetrahydrofuran) / 19 h / 0 - 30 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

2.2: Cooling with ice

3.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

6.1: hydrogenchloride; water / acetone / 12 h / 27 °C

With hydrogenchloride; sodium tetrahydroborate; water; ammonium formate; sodium hydride; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 24220-48-2
diethyl 2-(4'-benzyloxyphenyl)malonate

: 1258604-43-1
2-(4-((2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

5.1: hydrogenchloride; water / acetone / 12 h / 27 °C

With hydrogenchloride; sodium tetrahydroborate; water; ammonium formate; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; acetone; toluene;