(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Base Information

Chemical Name:(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid
CAS No.:1093066-22-8
Molecular Formula:C₂₇H₃₄N₂O₄
Molecular Weight:450.578
Hs Code.:

Synonyms:(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

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Chemical Property of (6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

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Technology Process of (6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

There total 13 articles about (6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1092938-55-0
(6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

: 1093066-22-8
(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid; With hydrogen; acetic acid; palladium 10% on activated carbon; at 20 ℃; under 760.051 Torr; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1092938-27-6
tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

: 1093066-22-8
(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogen; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1093066-22-8
(6R)-6-{[5-(4-Ethylcyclohexyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: diethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: 1.5 h / 210 °C

3: N-Bromosuccinimide / tetrachloromethane / 60 °C

4: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / 3 h / Reflux

5: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

6: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 80 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

8: hydrogen; acetic acid / palladium 10% on activated carbon / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; hydrogen; sodium hydride; sodium carbonate; acetic acid; diethylamine; trifluoroacetic acid; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;