tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Base Information

Chemical Name:tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate
CAS No.:1092938-27-6
Molecular Formula:C₃₁H₄₀N₂O₄
Molecular Weight:504.67
Hs Code.:

Synonyms:tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Suppliers and Price of tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

There total 11 articles about tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

: 1092938-90-3
2-(4-ethylcyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1092938-27-6
tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-27-6
tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 80 °C / Inert atmosphere

With hydrogen; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1092938-27-6
tert-butyl (6R)-6-{[5-(4-ethylcyclohex-1-en-1-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: 1.5 h / 210 °C

3: N-Bromosuccinimide / tetrachloromethane / 60 °C

4: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / 3 h / Reflux

5: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

6: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 80 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; sodium carbonate; diethylamine; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; tetrachloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;