((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

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Chemical Name:((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester
CAS No.:1026963-96-1
Molecular Formula:C₃₂H₃₆N₄O₄S
Molecular Weight:572.728
Hs Code.:

Synonyms:((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

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Chemical Property of ((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

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Technology Process of ((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

There total 8 articles about ((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1027481-51-1
(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (5-cyano-thiophen-3-ylmethyl)-amide

: 1026963-96-1
((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/jm030025j

Reference yield:

: 18799-85-4
5-iodo-thiophene-3-carboxaldehyde

: 1026963-96-1
((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaBH₄ / methanol / 20 °C

2: dimethylformamide / Heating

3: CBr₄; PPh₃ / CH₂Cl₂

4: NaH / tetrahydrofuran

5: HCl / ethyl acetate

6: EDC; HOBT; Et₃N / dimethylformamide / 20 °C

7: HCl / ethyl acetate / 20 °C

8: iPr₂NEt / acetonitrile / 20 °C

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j

Reference yield:

: 186552-07-8
4-bromomethyl-thiophene-2-carbonitrile

: 1026963-96-1
((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran

2: HCl / ethyl acetate

3: EDC; HOBT; Et₃N / dimethylformamide / 20 °C

4: HCl / ethyl acetate / 20 °C

5: iPr₂NEt / acetonitrile / 20 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j