ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate

Base Information

• Chemical Name: ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate
• CAS No.: 849241-95-8
• Molecular Formula: C₂₃H₂₆IN₅O₅
• Molecular Weight: 579.394
• Mol file: 849241-95-8.mol

Synonyms:ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate

Chemical Property of ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate

There total 1 articles about ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-(3-iodobenzyl)-2-chloro-9H-(2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranosyl)adenine (849242-02-0) + ethanol (64-17-5) + 3-iodobenzylamine hydrochloride (3718-88-5) → ethyl 1-deoxy-1-[N6-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate (849241-95-8)

Guidance literature:

N⁶-(3-iodobenzyl)-2-chloro-9H-(2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranosyl)adenine; ethanol; With thionyl chloride; at 20 ℃; for 3h;

3-iodobenzylamine hydrochloride; With TEA; In ethanol; for 6h; Heating;

DOI:10.1021/jm049408n

Reference yield:

ethyl 1-deoxy-1-[N6-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate (849241-95-8) → N-methyl-1-deoxy-1-[N6-(3-iodobenzyl)-9H-purin-9-yl]-3-C-methyl-β-D-ribofuranuronamide

Guidance literature:

Multi-step reaction with 2 steps

1: -20 - 20 °C

2: aq. HCOOH / 7 h / 45 °C

With formic acid;

DOI:10.1021/jm049408n

upstream raw materials:

N⁶-(3-iodobenzyl)-2-chloro-9H-(2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranosyl)adenine

ethanol

3-iodobenzylamine hydrochloride