(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

Base Information

Chemical Name:(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid
CAS No.:857506-63-9
Molecular Formula:C₂₆H₂₁F₂NO₅
Molecular Weight:465.453
Hs Code.:

Synonyms:(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

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Chemical Property of (4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

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Technology Process of (4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

There total 1 articles about (4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 857506-68-4
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 857506-63-9
(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

Guidance literature:: With formic acid; at 20 ℃; for 20h;

Reference yield: 92.0%

: 857506-63-9
(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

: 13081-32-8
D-leucine tert-butyl ester hydrochloride

: 857506-64-0
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

Guidance literature:: (4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid; D-leucine tert-butyl ester hydrochloride; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h;

With formic acid; at 40 - 45 ℃;

Reference yield:

: 857506-63-9
(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

: 3081-28-5,6404-30-4,16367-71-8,16874-17-2
D-phenylalanine tert-butyl ester

: 857506-80-0
C₃₉H₃₈F₂N₂O₆

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃;