1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one
CAS No.:857506-64-0
Molecular Formula:C₃₂H₃₂F₂N₂O₆
Molecular Weight:578.613
Hs Code.:

Synonyms:1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

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Chemical Property of 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

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Technology Process of 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

There total 1 articles about 1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 857506-63-9
(4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid

: 13081-32-8
D-leucine tert-butyl ester hydrochloride

: 857506-64-0
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

Guidance literature:: (4-{(2S,3R)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-oxoazetidin-2-yl}phenoxy)acetic acid; D-leucine tert-butyl ester hydrochloride; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h;

With formic acid; at 40 - 45 ℃;

Reference yield: 93.0%

: 857506-64-0
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 857506-66-2
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-((R)-1-{N-[1-(S)-(t-butoxycarbonyl)-3-(methyl)butyl]carbamoyl}-3-methylbutyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 65.0%

: 857506-64-0
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-[4-(N-[(R)-1-carboxy-3-methylbutyl]carbamoylmethoxy)phenyl]azetidin-2-one

: 48067-24-9
O-tert-butyl L-serine tert-butyl ester

: 857506-65-1
1-(4-fluorophenyl)-3-(R)-[2-(4-fluorobenzoyl)ethyl]-4-(S)-{4-[N-((R)-1-{N-[1-(S)-(t-butoxycarbonyl)-2-(t-butoxy)ethyl]carbamoyl}-3-methylbutyl)carbamoylmethoxy]phenyl}azetidin-2-one

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h;