(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

Base Information

Chemical Name:(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one
CAS No.:347840-58-8
Molecular Formula:C₃₃H₄₁BrO₄Si
Molecular Weight:609.676
Hs Code.:

Synonyms:(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

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Chemical Property of (2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

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Technology Process of (2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

There total 10 articles about (2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 72345-23-4
(2S,4S)-pentane-2,4-diol

: 347840-57-7
2-bromo-3-(tert-butyl-diphenyl-silanyloxymethyl)-4,4-dimethoxy-6-(3-methyl-but-2-enyl)-cyclohexa-2,5-dienone

: 347840-58-8
(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene; at 80 ℃; for 0.333333h;
DOI:10.1021/ol0159367

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 347840-58-8
(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 94 percent / Br₂ / CHCl₃ / 1.5 h / 20 °C

2.1: 94 percent / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

3.1: 72 percent / NaH / tetrahydrofuran / 6 h / 65 °C

4.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

5.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

6.1: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

7.1: NaH / toluene / 4 h / 50 °C

7.2: 35 percent / toluene / 12 h / -30 °C

8.1: 31 percent / montmorillonite KSF / benzene / 48 h / 20 °C

9.1: 83 percent / PhI(OAc)2 / 0.33 h / 20 °C

10.1: 80 percent / PPTS / benzene / 0.33 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; Montmorillonite KSF; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; bromine; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/ol0159367

Reference yield:

: 241127-72-0
2-bromo-3,6-dihydroxy-benzaldehyde

: 347840-58-8
(2S,4S)-8-Bromo-7-(tert-butyl-diphenyl-silanyloxymethyl)-2,4-dimethyl-10-(3-methyl-but-2-enyl)-1,5-dioxa-spiro[5.5]undeca-7,10-dien-9-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 94 percent / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

2.1: 72 percent / NaH / tetrahydrofuran / 6 h / 65 °C

3.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

4.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

5.1: 93 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

6.1: NaH / toluene / 4 h / 50 °C

6.2: 35 percent / toluene / 12 h / -30 °C

7.1: 31 percent / montmorillonite KSF / benzene / 48 h / 20 °C

8.1: 83 percent / PhI(OAc)2 / 0.33 h / 20 °C

9.1: 80 percent / PPTS / benzene / 0.33 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; Montmorillonite KSF; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/ol0159367