5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

Base Information

Chemical Name:5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid
CAS No.:159693-77-3
Molecular Formula:C₁₁H₅Cl₂F₂NO₃
Molecular Weight:308.068
Hs Code.:

Synonyms:5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

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Chemical Property of 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

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Technology Process of 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

There total 3 articles about 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 159693-07-9
methyl 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylate

: 159693-77-3
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

Guidance literature:: With hydrogenchloride; acetic acid; for 72h; Heating;
DOI:10.1021/jf00049a040

Reference yield:

: 3848-36-0
4-chlorobenzaldoxime

: 159693-77-3
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

3: 64 percent / conc. aq. HCl, CH₃COOH / 72 h / Heating

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040

Reference yield:

: 28123-63-9
4-chlorobenzohydroximoyl chloride

: 159693-77-3
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

2: 64 percent / conc. aq. HCl, CH₃COOH / 72 h / Heating

With hydrogenchloride; sodium hydroxide; acetic acid; In dichloromethane;
DOI:10.1021/jf00049a040