5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

Base Information

Chemical Name:5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride
CAS No.:159693-78-4
Molecular Formula:C₁₁H₄Cl₃F₂NO₂
Molecular Weight:326.514
Hs Code.:

Synonyms:5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

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Chemical Property of 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

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Technology Process of 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

There total 4 articles about 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 159693-77-3
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylic acid

: 159693-78-4
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Heating;
DOI:10.1021/jf00049a040

Reference yield:

: 159693-07-9
methyl 5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarboxylate

: 159693-78-4
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / conc. aq. HCl, CH₃COOH / 72 h / Heating

2: 80 percent / oxalyl chloride, DMF / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jf00049a040

Reference yield:

: 3848-36-0
4-chlorobenzaldoxime

: 159693-78-4
5-(chlorodifluoromethyl)-3-(4-chlorophenyl)-4-isoxazolecarbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

3: 64 percent / conc. aq. HCl, CH₃COOH / 72 h / Heating

4: 80 percent / oxalyl chloride, DMF / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040