N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

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Chemical Name:N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester
CAS No.:254905-59-4
Molecular Formula:C₂₃H₃₇N₃O₃
Molecular Weight:403.565
Hs Code.:

Synonyms:N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

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Chemical Property of N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

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Technology Process of N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

There total 5 articles about N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138022-01-2
4-((dimethylamino)methyl)piperidine-1-carboxylic acid tert-butyl ester

: 172281-72-0,172281-93-5
N,N-dimethyl-N-((piperidin-4-yl)methyl)amine dihydrochloride

: 254905-59-4
N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate;

Reference yield:

: 37553-65-4,64263-83-8,85466-66-6
N-tert-butoxycarbonyl-N-methyl-D-phenylalanine

: 172281-72-0,172281-93-5
N,N-dimethyl-N-((piperidin-4-yl)methyl)amine dihydrochloride

: 254905-59-4
N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: N-tert-butoxycarbonyl-N-methyl-D-phenylalanine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

N,N-dimethyl-N-((piperidin-4-yl)methyl)amine dihydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 72h;
DOI:10.1016/S0223-5234(02)01370-3

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 254905-59-4
N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: 4.56 g / CH₂Cl₂; dimethylformamide; ethanol / 72 h / 0 - 20 °C

2.1: 4.07 g / NaBH₄; I₂ / tetrahydrofuran / 16 h / Heating

3.1: HCl / ethyl acetate / 0.5 h / 20 °C

4.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

4.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 72 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(02)01370-3