138022-01-2

Basic information

• Product Name: tert-Butyl 4-((dimethylamino)methyl)piperidine-1-carboxylate
• Synonyms: tert-Butyl 4-((dimethylamino)methyl)piperidine-1-carboxylate
• CAS NO: 138022-01-2
• Molecular Formula: C₁₃H₂₆N₂O₂
• Molecular Weight: 242
• Mol File: 138022-01-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 304.6±15.0 °C(Predicted)
• Appearance: /
• Density: 0.985±0.06 g/cm3(Predicted)
• PKA: 9.48±0.28(Predicted)
• CAS DataBase Reference: tert-Butyl 4-((dimethylamino)methyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-((dimethylamino)methyl)piperidine-1-carboxylate(138022-01-2)
• EPA Substance Registry System: tert-Butyl 4-((dimethylamino)methyl)piperidine-1-carboxylate(138022-01-2)

Safety Data

• Hazardous Substances Data: 138022-01-2(Hazardous Substances Data)

Upstream product

• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 254905-58-3 4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 254905-63-0 {(3E)-4-[N-((1R)-1-{N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamoyl}-2-(2-naphthyl)ethyl)-N-methylcarbamoyl]-1,1-dimethylbut-3-enyl}carbamic acid tert-butyl ester 
• 254905-61-8 N-((1R)-1-{N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamoyl}-2-(2-naphthyl)ethyl)-N-methylcarbamic acid tert-butyl ester 
• 254905-62-9 (2R)-N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methyl-2-(methylamino)-3-(2-naphthyl)propionamide 
• 254905-59-4 N-[(1R)-1-benzyl-2-(4-((dimethylamino)methyl)piperidin-1-yl)-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester 
• 254905-60-7 (2R)-1-(4-((dimethylamino)methyl)piperidin-1-yl)-2-(methylamino)-3-phenylpropan-1-one 
• 172281-72-0 N,N-dimethyl-N-((piperidin-4-yl)methyl)amine dihydrochloride 

Relevant articles and documents

The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency

In order to obtain more potent growth hormone secretagogues, a comparison of ipamorelin and NN703 suggested the addition of a polar group at the C-terminus of NN703. A study was conducted using constrained amines for this purpose. Here, substituted 4-piperidinylamino- and 4-dimethylaminopiperidino-substitutents were found to give the most active compounds. A replacement of the 4-dimethylaminopiperidino-substituent with 4-hydroxypiperidino resulted in a series of compounds, which showed in vitro activity with EC50 values in the low nanomolar range, and favourable kinetic properties, such as 40% oral bioavailability. The most promising compound was also tested in a swine in vivo model, resulting in a growth hormone level with a Cmax of over 40 ng mL-1.