benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate
CAS No.:1447194-98-0
Molecular Formula:C₃₅H₃₀N₂O₄S
Molecular Weight:574.7
Hs Code.:

Synonyms:benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Suppliers and Price of benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

There total 6 articles about benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 1447194-98-0
benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

2: lithium aluminium tetrahydride / tetrahydrofuran / -25 °C

3: tin(ll) chloride / dichloromethane

4: sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 40 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; sulfuryl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/anie.201302106

Reference yield:

: 299207-24-2
(9H-fluoren-9-yl)methyl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 1447194-98-0
benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / -25 °C

2: tin(ll) chloride / dichloromethane

3: sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

4: ethanol / 40 °C

With lithium aluminium tetrahydride; sulfuryl dichloride; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/anie.201302106

Reference yield:

: 1447194-69-5
benzyl (4S)-4-(N-fmoc)amino-3-oxo-5-phenylpentanoate

: 1447194-98-0
benzyl 4-[(1S)-1-(N-fmoc)amino-2-phenethyl]-2-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

2: ethanol / 40 °C

With sulfuryl dichloride; In ethanol; dichloromethane;
DOI:10.1002/anie.201302106