1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

Base Information

Chemical Name:1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea
CAS No.:1448985-09-8
Molecular Formula:C₂₅H₃₃FN₆O₄
Molecular Weight:500.573
Hs Code.:

Synonyms:1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

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Chemical Property of 1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

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Technology Process of 1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

There total 10 articles about 1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448987-83-4
trifluoromethanesulfonic acid 6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl ester

: 1448987-84-5
1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

: 1448985-09-8
1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-09-8
1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

1.2: 2 h / 4 °C

2.1: magnesium bis(monoperoxyphthalate)hexahydrate / acetonitrile; ethanol / 2 h / 20 °C

3.1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

5.1: triethylamine / dichloromethane / 3 h / 4 °C

6.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.33 h / 100 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; magnesium bis(monoperoxyphthalate)hexahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1448987-80-1
4-benzyloxy-6-ethyl-2-methanesulfonyl-8,8-dimethyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-09-8
1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

3: triethylamine / dichloromethane / 3 h / 4 °C

4: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.33 h / 100 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;