4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Base Information

Chemical Name:4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one
CAS No.:1448987-79-8
Molecular Formula:C₁₉H₂₃N₃O₃S
Molecular Weight:373.476
Hs Code.:

Synonyms:4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

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Chemical Property of 4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

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Technology Process of 4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

There total 4 articles about 4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 100-51-6,185532-71-2
benzyl alcohol

: 1448987-79-8
4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: benzyl alcohol; With sodium hydride; In tetrahydrofuran; at 4 ℃; for 0.25h;

4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one; In tetrahydrofuran; at 4 ℃; for 2h;

Reference yield:

: 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbonyl chloride

: 1448987-79-8
4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 4 h / -70 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 5 h / 55 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

3.2: 2 h / 4 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 313339-35-4
4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 1448987-79-8
4-benzyloxy-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 18 h / 80 °C

2.1: triethylamine / tetrahydrofuran / 4 h / -70 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 5 h / 55 °C

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

4.2: 2 h / 4 °C

With thionyl chloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;