1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

Base Information

Chemical Name:1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea
CAS No.:1448987-84-5
Molecular Formula:C₁₅H₂₂BFN₂O₃
Molecular Weight:308.161
Hs Code.:

Synonyms:1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

Suppliers and Price of 1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

There total 1 articles about 1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 557-66-4
ethanamine hydrochloride

: 819058-34-9
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1448987-84-5
1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

Guidance literature:: 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; With triethylamine; In dichloromethane; at 4 ℃; for 0.0833333h;

bis(trichloromethyl) carbonate; In dichloromethane; at 20 ℃; for 1.5h;

ethanamine hydrochloride; With potassium carbonate; In dichloromethane; for 2h;

Reference yield:

: 1448987-83-4
trifluoromethanesulfonic acid 6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl ester

: 1448987-84-5
1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

: 1448985-09-8
1-ethyl-3-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-fluorophenyl}urea

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1448987-84-5
1-ethyl-3-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

: 1448987-87-8
(S)-2-(4-chloro-8,8-dimethyl-2-methylsulfanyl-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-ylmethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1448987-88-9
(S)-2-{4-[4-(3-ethylureido)-3-fluorophenyl]-8,8-dimethyl-2-methylsulfanyl-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-ylmethyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 110 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;