4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide

Base Information

• Chemical Name: 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide
• CAS No.: 1412891-45-2
• Molecular Formula: C₂₀H₁₆F₂N₄O₂S
• Molecular Weight: 414.435
• Mol file: 1412891-45-2.mol

Synonyms:4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide

Chemical Property of 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide

There total 7 articles about 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

4-(3-aminophenoxy)-N-methylpicolinamide (284462-78-8) + 3,4-difluorophenyl isothiocyanate (113028-75-4) → 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide (1412891-45-2)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

4-chloro-N-methylpicolinamide (220000-87-3) → 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide (1412891-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

m-Hydroxyaniline (591-27-5) → 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide (1412891-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.031

upstream raw materials:

m-Hydroxyaniline

4-chloro-N-methylpicolinamide

2-Picolinic acid

4-(3-aminophenoxy)-N-methylpicolinamide