284462-78-8

Basic information

• Product Name: 4-(3-Aminophenoxy)-N-methylpicolinamide
• Synonyms: 2-Pyridinecarboxamide, 4-(3-aminophenoxy)-N-methyl-
• CAS NO: 284462-78-8
• Molecular Formula: C₁₃H₁₃N₃O₂
• Molecular Weight: 243.265
• Mol File: 284462-78-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 472.2 °C at 760 mmHg
• Flash Point: 239.4 °C
• Density: 1.241 g/cm³
• CAS DataBase Reference: 4-(3-Aminophenoxy)-N-methylpicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Aminophenoxy)-N-methylpicolinamide(284462-78-8)
• EPA Substance Registry System: 4-(3-Aminophenoxy)-N-methylpicolinamide(284462-78-8)

Safety Data

• Hazardous Substances Data: 284462-78-8(Hazardous Substances Data)

Upstream product

• 220000-87-3 4-chloro-N-methylpicolinamide 
• 554-84-7 meta-nitrophenol 
• 591-27-5 m-Hydroxyaniline 
• 827029-02-7 C₁₃H₁₁N₃O₄ 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 1412891-41-8 4-(3-(3-(2,4-dichlorophenyl)thioureido)phenoxy)-N-methylpicolinamide 
• 1412891-42-9 4-(3-(3-(4-chlorophenyl)thioureido)phenoxy)-N-methylpicolinamide 
• 1412891-45-2 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-methylpicolinamide 
• 1412891-49-6 N-methyl-4-(3-(3-(3-(trifluoromethyl)phenyl)thioureido)phenoxy)picolinamide 
• 1412891-55-4 4-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenoxy)-N-methylpicolinamide 
• 1412891-60-1 N-methyl-4-(3-(3-(4-(trifluoromethoxy)phenyl)thioureido)phenoxy)picolinamide 
• 1400989-32-3 1-(3-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)-3-(3-fluorophenyl)urea 
• 1400989-36-7 4-(3-(benzene-sulfonylamino)phenoxy)-N-methylpyridine-2-carboxamide 
• 1400989-34-5 4-(3-(benzene-carbonylamino)phenoxy)-N-methylpyridine-2-carboxamide 
• 1400989-33-4 4-(3-(3-(trifluoromethyl)benzene-sulfonylamino)phenoxy)-N-methylpyridine-2-carboxamide 
• 1400989-35-6 4-(3-(3-(trifluoromethoxy)benzylamino)phenoxy)-N-methylpyridine-2-carboxamide 
• 284462-92-6 3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline 
• 220000-87-3 4-chloro-N-methylpicolinamide 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

NOVEL SUBSTITUTED PYRIDINYLOXY AND PYRIMIDINYLOXY AMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.

PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS

Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G', and G" represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.