6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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Chemical Name:6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
CAS No.:1402544-66-4
Molecular Formula:C₅₄H₆₃N₈O₇P
Molecular Weight:967.117
Hs Code.:

6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Synonyms:6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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Chemical Property of 6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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Technology Process of 6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

There total 3 articles about 6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1402544-65-3
6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1402544-66-4
6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1002/chem.201103385

Reference yield:

: 1033295-11-2
3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-6-hexynyl-2H-pyrrolo[2,3-d]pyrimidin-2-one

: 1402544-66-4
6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: copper(II) sulfate; sodium L-ascorbate; benzoic acid / water; tert-butyl alcohol / 24 h / 20 °C

2: pyridine

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

With pyridine; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; benzoic acid; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/chem.201103385

Reference yield:

: 622-79-7
benzyl azide

: 1402544-66-4
6-{4-[1-benzyl-1H-(1,2,3)-triazole-4-yl]butyl}-3-(2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidin-2(3H)one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: copper(II) sulfate; sodium L-ascorbate; benzoic acid / water; tert-butyl alcohol / 24 h / 20 °C

2: pyridine

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

With pyridine; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; benzoic acid; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/chem.201103385