phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol

Base Information

• Chemical Name: phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol
• CAS No.: 1426532-92-4
• Molecular Formula: C₂₃H₁₆F₃NO
• Molecular Weight: 379.381
• Mol file: 1426532-92-4.mol

Synonyms:phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol

Chemical Property of phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol

There total 3 articles about phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2-bromoquinolin-4-yl)(pyridin-2-yl)methanol + 4-trifluoromethylphenylboronic acid (128796-39-4) → phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol (1426532-92-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In ethanol; water; toluene; at 105 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol400150z

Reference yield:

2,4-dibromoquinoline (20151-40-0) → phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol (1426532-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / 105 °C / Inert atmosphere

With TurboGrignard; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; ethanol; water; toluene; 2.1: |Suzuki Coupling;

DOI:10.1021/ol400150z

Reference yield:

benzaldehyde (100-52-7) → phenyl(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)methanol (1426532-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / 105 °C / Inert atmosphere

With TurboGrignard; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; ethanol; water; toluene; 2.1: |Suzuki Coupling;

DOI:10.1021/ol400150z

upstream raw materials:

2,4-dibromoquinoline

benzaldehyde

4-trifluoromethylphenylboronic acid

Refernces