(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

Base Information

Chemical Name:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine
CAS No.:228267-25-2
Molecular Formula:C₂₀H₂₆N₂O₅
Molecular Weight:374.437
Hs Code.:

Synonyms:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

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Technology Process of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

There total 9 articles about (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 228267-25-2
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

Guidance literature:

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methanesulfonyloxymethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 228267-25-2
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂; methanol / 0.5 h / 0 °C

2: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

3: conc. HCl / methanol / 0.5 h / Heating

4: 82.0 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

With hydrogenchloride; sodium hydroxide; In methanol; dichloromethane; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8

Reference yield:

: 1027089-21-9
4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methylaminomethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 228267-25-2
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

2: conc. HCl / methanol / 0.5 h / Heating

3: 82.0 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

With hydrogenchloride; sodium hydroxide; In methanol; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8