(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Base Information

Chemical Name:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine
CAS No.:228267-24-1
Molecular Formula:C₂₇H₄₄N₂O₅Si
Molecular Weight:504.742
Hs Code.:

Synonyms:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

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Chemical Property of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

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Technology Process of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

There total 7 articles about (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 228267-22-9
(2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine

: 228267-24-1
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: Et₃N / CH₂Cl₂ / -39 °C

3: CH₂Cl₂; methanol / 0.5 h / 0 °C

4: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

With sodium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methanesulfonyloxymethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 228267-24-1
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂; methanol / 0.5 h / 0 °C

2: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

With sodium hydroxide; In methanol; dichloromethane; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8

Reference yield:

: 228267-23-0
(2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[4-(hydroxymethyl)phenyl]pyrrolidine

: 228267-24-1
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / -39 °C

2: CH₂Cl₂; methanol / 0.5 h / 0 °C

3: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

With sodium hydroxide; triethylamine; In methanol; dichloromethane; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8