(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Base Information

Chemical Name:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine
CAS No.:228267-26-3
Molecular Formula:C₂₁H₂₈N₂O₇S
Molecular Weight:452.529
Hs Code.:

Synonyms:(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Chemical Property:

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Technology Process of (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

There total 11 articles about (2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 124-63-0
methanesulfonyl chloride

: 228267-25-2
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-hydroxypyrrolidine

: 228267-26-3
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; at -40 ℃;
DOI:10.1016/S0968-0896(01)00430-8

Reference yield: 92.0%

: 228267-26-3
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methanesulfonyloxymethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 228267-26-3
(2R,4R)-2-[4-(N-allyloxycarbonyl-N-methylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂; methanol / 0.5 h / 0 °C

2: 110.5 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

3: conc. HCl / methanol / 0.5 h / Heating

4: 82.0 g / aq. NaOH / benzene; H₂O / 5 °C / pH 9.0

5: 92 percent / Et₃N / CH₂Cl₂ / -40 °C

With hydrogenchloride; sodium hydroxide; triethylamine; In methanol; dichloromethane; water; benzene;
DOI:10.1016/S0968-0896(01)00430-8