3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

Base Information

Chemical Name:3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione
CAS No.:1308788-88-6
Molecular Formula:C₁₈H₁₇ClN₂O₂
Molecular Weight:328.798
Hs Code.:

Synonyms:3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

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Chemical Property of 3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

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Technology Process of 3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

There total 5 articles about 3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 201230-82-2
carbon monoxide

: 1308788-41-1
3-(4-chlorophenyl)-2,2-dimethyl-N-(pyridin-2-ylmethyl)propanamide

: 1308788-88-6
3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

Guidance literature:: With dodecacarbonyl-triangulo-triruthenium; ethene; water; In toluene; at 160 ℃; for 120h; under 12920.9 Torr; regioselective reaction; Autoclave;
DOI:10.1021/ja2001709

Reference yield:

: 57145-14-9
α-(4-Chloro-benzyl)-isobutyric acid

: 1308788-88-6
3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

3: dodecacarbonyl-triangulo-triruthenium; ethene; water / toluene / 120 h / 160 °C / 12920.9 Torr / Autoclave

With thionyl chloride; dodecacarbonyl-triangulo-triruthenium; ethene; water; In dichloromethane; toluene;
DOI:10.1021/ja2001709

Reference yield:

: 14305-27-2
3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester

: 1308788-88-6
3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / methanol / 60 °C

1.2: pH 2

2.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

3.1: dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: dodecacarbonyl-triangulo-triruthenium; ethene; water / toluene / 120 h / 160 °C / 12920.9 Torr / Autoclave

With thionyl chloride; dodecacarbonyl-triangulo-triruthenium; ethene; water; sodium hydroxide; In methanol; dichloromethane; toluene;
DOI:10.1021/ja2001709