(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

Base Information

Chemical Name:(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid
CAS No.:1253795-20-8
Molecular Formula:C₁₈H₂₅IN₂O₆
Molecular Weight:492.311
Hs Code.:

Synonyms:(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

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Chemical Property of (S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

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Technology Process of (S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

There total 7 articles about (S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1253795-19-5
(S)-methyl 2-((S )-2-((tert-butoxycarbonyl)(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)propanoate

: 1253795-20-8
(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

Guidance literature:: With trimethyltin(IV) hydroxide; In 1,2-dichloro-ethane; at 70 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/chem.201000924

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1253795-20-8
(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; sodium carbonate / water; tetrahydrofuran / 0 - 20 °C / pH 7-9

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

3: potassium carbonate / acetone / Reflux

4: silver sulfate; iodine / methanol

5: lithium hydroxide; water / tetrahydrofuran

With water; iodine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; silver sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: (S)-methyl 2-((S )-2-((tert-butoxycarbonyl)(methyl)amino)-2-(4-methoxyphenyl)acetamido)propanoate

: 1253795-20-8
(S)-3-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetamido)-2-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: silver sulfate; iodine / methanol

2: lithium hydroxide; water / tetrahydrofuran

With water; iodine; silver sulfate; lithium hydroxide; In tetrahydrofuran; methanol;