(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate
• CAS No.: 1086703-01-6
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.293
• Mol file: 1086703-01-6.mol

Synonyms:(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate

Chemical Property of (S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate

There total 1 articles about (S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5) → (S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate (1086703-01-6)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Reflux;

DOI:10.1055/s-2008-1078209

Reference yield: 68.0%

(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate (1086703-01-6) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-((tert-butoxycarbonyl)(methyl)amino)-2-(4-hydroxyphenyl)acetic acid

Guidance literature:

(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere; Sealed tube;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; sodium hydroxide; In water; at 20 ℃; for 12h;

DOI:10.1021/jacs.8b00087

Reference yield: 67.0%

(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate (1086703-01-6) + diazomethyl-trimethyl-silane (18107-18-1) → (S)-tert-butyl 4-(4-methoxyphenyl)-5-oxooxazolidine-3-carboxylate (1253795-08-2)

Guidance literature:

In methanol; hexane; dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/chem.201000924

upstream raw materials:

formaldehyd

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

Downstream raw materials:

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

(S)-tert-butyl 4-(4-methoxyphenyl)-5-oxooxazolidine-3-carboxylate

C₄₃H₅₅N₅O₁₁