N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

Base Information

• Chemical Name: N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide
• CAS No.: 1187028-61-0
• Molecular Formula: C₂₄H₂₇N₃O₆
• Molecular Weight: 453.495
• Mol file: 1187028-61-0.mol

Synonyms:N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

Chemical Property of N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

There total 7 articles about N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H29N3O7 → N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide (1187028-61-0)

Guidance literature:

In 1,4-dioxane; at 100 ℃; for 2h;

DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

4-formyl-3-methyl benzoic acid (24078-23-7) → N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide (1187028-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1,4-dioxane / 2 h / 100 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

4-bromo-3-methylbenzoic acid (7697-28-1) → N-((S)-3-{2-ethyl-4-[5-(4-formyl-3-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide (1187028-61-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene / 40 h / 20 - 80 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 18 h / 20 °C

5.1: 1,4-dioxane / 2 h / 100 °C

With n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2016.03.048

upstream raw materials:

4-formyl-3-methyl benzoic acid

4-bromo-3-methylbenzoic acid

tert-butyl 4-bromo-3-methylbenzoate

tert-butyl 4-formyl-3-methylbenzoate

Downstream raw materials:

(S)-N-(3-(2-ethyl-4-(5-(4-((ethyl(methyl)amino)methyl)-3-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

(S)-N-(3-(2-ethyl-4-(5-(4-((isobutylamino)methyl)-3-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

(S)-N-(3-(2-ethyl-6-methyl-4-(5-(3-methyl-4-(pyrrolidin-1-ylmethyl)phenyl)-1,2,4-oxadiazol-3-yl)phenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

(S)-N-(3-(4-(5-(4-((diethylamino)methyl)-3-methylphenyl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide