1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

Base Information

Chemical Name:1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid
CAS No.:1429439-90-6
Molecular Formula:C₂₀H₁₉NO₆
Molecular Weight:369.374
Hs Code.:

Synonyms:1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

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Chemical Property of 1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

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Technology Process of 1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

There total 9 articles about 1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 1429439-90-6
1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: pH 1 - 2 / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / water / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

7.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

8.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

8.2: 48 h / Inert atmosphere; Reflux

9.1: water; potassium hydroxide / methanol / 1 h / Inert atmosphere; Reflux

With hydrogenchloride; n-butyllithium; water; boron tribromide; sodium hydride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 5653-51-0
6-amino-2,3-dimethoxybenzoic acid

: 1429439-90-6
1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

5.2: 48 h / Inert atmosphere; Reflux

6.1: water; potassium hydroxide / methanol / 1 h / Inert atmosphere; Reflux

With hydrogenchloride; water; boron tribromide; sodium hydride; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 102421-43-2
N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline

: 1429439-90-6
1-ethyl-5-hydroxy-6-((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: pH 1 - 2 / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / water / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

6.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

7.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

7.2: 48 h / Inert atmosphere; Reflux

8.1: water; potassium hydroxide / methanol / 1 h / Inert atmosphere; Reflux

With hydrogenchloride; n-butyllithium; water; boron tribromide; sodium hydride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;