(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate

Base Information

Chemical Name:(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate
CAS No.:608142-28-5
Molecular Formula:C₈H₁₅NO₃*C₁₂H₁₉NO₄S
Molecular Weight:446.565
Hs Code.:
Mol file:608142-28-5.mol

Synonyms:(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-D-leucine salt

Suppliers and Price of (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-Acetyl-D-leucine Salt is an intermediate in the synthesis of (R)-Apremilast (A729705), an enantiomer of Apremilast (A729700), an oral phosphodiesterase 4 inhibitor is used in the treatment of psoriatic arthritis.

Technology Process of (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate

There total 4 articles about (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (R)-2-acetamido-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 253168-94-4
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

: 19764-30-8
N-acetyl-D-leucine

: 608142-28-5
(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-D-leucine salt

Guidance literature:: In methanol; at 20 ℃; for 8h; Reflux; Inert atmosphere;

Reference yield:

: 621-59-0
isovanillin

: 608142-28-5
(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-D-leucine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2.2: 20 °C / Cooling with salt-ice; Inert atmosphere

3.1: hydrogenchloride; water / diethyl ether / 0.5 h / 20 °C

3.2: pH 12 / Cooling with ice

4.1: methanol / 8 h / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; n-butyllithium; water; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 608142-28-5
(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-D-leucine salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 20 °C / Cooling with salt-ice; Inert atmosphere

2.1: hydrogenchloride; water / diethyl ether / 0.5 h / 20 °C

2.2: pH 12 / Cooling with ice

3.1: methanol / 8 h / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; n-butyllithium; water; In tetrahydrofuran; methanol; diethyl ether; hexane;