3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide

Base Information

• Chemical Name: 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide
• CAS No.: 323579-82-4
• Molecular Formula: C₁₉H₁₉ClN₂O₅
• Molecular Weight: 390.823

Synonyms:3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide

Chemical Property of 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide

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Technology Process of 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide

There total 2 articles about 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloropropionyl chloride (625-36-5) + 2-[1-Furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyric acid hydrazide (323579-72-2) → 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide (323579-82-4)

Guidance literature:

In benzene; at 0 - 15 ℃; for 5h;

DOI:10.3390/50600895

Reference yield:

(E)-enol lactone of α-(2-furfurylidene)-β-(p-methoxybenzoyl)propionic acid (104637-87-8) → 3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide (323579-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NH₂NH₂*H₂O / ethanol / 20 °C

2: 83 percent / benzene / 5 h / 0 - 15 °C

With hydrazine hydrate; In ethanol; benzene;

DOI:10.3390/50600895

Reference yield: 82.0%

3-Chloro-propionic acid N'-[2-[1-furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyryl]-hydrazide (323579-82-4) → (E)-3-[5-(2-Chloro-ethyl)-[1,3,4]oxadiazol-2-yl]-4-furan-2-yl-1-(4-methoxy-phenyl)-but-3-en-1-one

Guidance literature:

With trichlorophosphate; at 106 ℃; for 1h;

DOI:10.3390/50600895

upstream raw materials:

2-chloropropionyl chloride

2-[1-Furan-2-yl-meth-(E)-ylidene]-4-(4-methoxy-phenyl)-4-oxo-butyric acid hydrazide

(E)-enol lactone of α-(2-furfurylidene)-β-(p-methoxybenzoyl)propionic acid

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