(2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate

Base Information

• Chemical Name: (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate
• CAS No.: 1401067-09-1
• Molecular Formula: C₂₁H₂₆F₆O₄
• Molecular Weight: 456.425
• Mol file: 1401067-09-1.mol

Synonyms:(2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate

Chemical Property of (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate

There total 8 articles about (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2R,3S)-3-(tert-butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid (1401067-03-5) + benzyl bromide (100-39-0) → (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate (1401067-09-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield: 65.0%

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid (1401067-08-0) + benzyl bromide (100-39-0) + 3,3,3-trifluoropropyl trifluoromethanesulfonate (120097-63-4) → (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate (1401067-09-1)

Guidance literature:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.11667h;

3,3,3-trifluoropropyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 - -25 ℃; for 2.05h;

benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 65.0%

(2R)-3-(tert-butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid + benzyl bromide (100-39-0) → (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate (1401067-09-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

benzyl bromide

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

3,3,3-trifluoropropyl trifluoromethanesulfonate

5,5,5-trifluoropentanoic acid

Downstream raw materials:

tert-butyl (2S,3R)-6,6,6-trifluoro-3-(((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoate

(2S,3R)-6,6,6-trifluoro-3-((⁽³⁵⁾-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoic acid

(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide

(2R,3S)-N-((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide