R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Base Information

Chemical Name:R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid
CAS No.:1401067-08-0
Molecular Formula:C₁₁H₁₇F₃O₄
Molecular Weight:270.249
Hs Code.:
Mol file:1401067-08-0.mol

Synonyms:(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Suppliers and Price of R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
(2R)-2-(2-tert-Butoxy-2-oxoethyl)-5,5,5-trifluoropentanoicacid
1g
$ 1200.00

Total 7 raw suppliers

Chemical Property of R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Chemical Property:

Boiling Point:305.5±42.0 °C(Predicted)
PKA:4.22±0.23(Predicted)
Density:1.200±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(2R)-2-(2-tert-Butoxy-2-oxoethyl)-5,5,5-trifluoropentanoicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid

There total 6 articles about R)-2-(2-tert-butoxy-2-oxoethyl)-5,5,5-trifluoropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1401067-07-9
tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

: 1401067-08-0
(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Guidance literature:: With water; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 1.16667h;

Reference yield: 83.0%

: 1401067-08-0
(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Guidance literature:

Reference yield:

: 407-62-5
5,5,5-trifluoropentanoic acid

: 1401067-08-0
(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h

1.2: 0.58 h / -78 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 °C

3.1: lithium hydroxide; dihydrogen peroxide; water / tetrahydrofuran / 1.17 h / 0 °C

With oxalyl dichloride; water; dihydrogen peroxide; sodium hexamethyldisilazane; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane;