ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate

Base Information

• Chemical Name: ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate
• CAS No.: 138998-46-6
• Molecular Formula: C₁₄H₁₄F₃NO₃
• Molecular Weight: 301.265
• Mol file: 138998-46-6.mol

Synonyms:ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate

Chemical Property of ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate

There total 4 articles about ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) + 2,4,5-trifluorobenzoyl chloride (88419-56-1) → ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate (138998-46-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 180 ℃; for 0.025h; under 9050.33 Torr; Reagent/catalyst; Solvent; Flow reactor; Inert atmosphere;

DOI:10.1002/anie.201703812

Reference yield: 91.0%

ethyl 2,4,5-trifluorobenzoylacetate (98349-24-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate (138998-46-6)

Guidance literature:

at 50 - 55 ℃; for 2h; neat (no solvent);

DOI:10.2174/157017811799304322

Reference yield:

2,4,5-trifluorobenzoic acid (446-17-3) → ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate (138998-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide; toluene / 55 - 60 °C

2: triethylamine / toluene / 55 - 60 °C

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide; toluene;

DOI:10.2174/157017811799304322

upstream raw materials:

ethyl 3-(dimethylamino)acrylate

2,4,5-trifluorobenzoyl chloride

2,4,5-trifluorobenzoic acid

ethyl 2,4,5-trifluorobenzoylacetate

Downstream raw materials:

ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate

1-(tert-butyl)-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

1-cyclopropyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

4-methoxybenzyl 5-chloro-1-cyclopropyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylate