3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester

Base Information

• Chemical Name: 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester
• CAS No.: 101799-76-2
• Molecular Formula: C₁₅H₁₄F₃NO₃
• Molecular Weight: 313.276
• Mol file: 101799-76-2.mol

Synonyms:3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester

Chemical Property of 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester

Chemical Property:

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester

There total 14 articles about 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,4,5-trifluorobenzoyl chloride (88419-56-1) + Ethyl 3-(Cyclopropylamino)-2-propenoate (96568-08-0) → 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester (101799-76-2)

Guidance literature:

Ethyl 3-(Cyclopropylamino)-2-propenoate; With lithium hexamethyldisilazane; In toluene; at -78 ℃; for 0.5h;

2,4,5-trifluorobenzoyl chloride; In toluene; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.8b03222

Reference yield: 96.0%

ethyl 3-(dimethylamino)-2-(2,4,5-trifluorobenzoyl)prop-2-enoate (138998-46-6) + Cyclopropylamine (765-30-0) → 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester (101799-76-2)

Guidance literature:

In acetonitrile; at 25 ℃; for 0.0166667h; Flow reactor; Inert atmosphere;

DOI:10.1002/anie.201703812

Reference yield: 94.0%

α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester (101799-75-1) + Cyclopropylamine (765-30-0) → 3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester (101799-76-2)

Guidance literature:

In ethanol; for 1h; Ambient temperature;

upstream raw materials:

α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester

Cyclopropylamine

propanedioic acid monoethyl ester dilithium salt

orthoformic acid triethyl ester

Downstream raw materials:

1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate ethyl ester

ciprofloxacin hydrochloride

ciprofloxacin

1-cyclopropyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-3-quinoline-carboxylic acid