2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Base Information

Chemical Name:2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide
CAS No.:1272355-01-7
Molecular Formula:C₂₈H₂₃N₇O₂S
Molecular Weight:521.602
Hs Code.:

Synonyms:2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Suppliers and Price of 2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

There total 10 articles about 2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1272356-87-2
6-bromo-2-methylimidazo[1,2-a]pyridine-8-sulfonamide

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272355-01-7
2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Guidance literature:: 6-bromo-2-methylimidazo[1,2-a]pyridine-8-sulfonamide; With hexamethyldistannane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1272355-01-7
2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 3 h / Reflux

2.1: tetrahydrofuran / 2 h / 0 - 20 °C

3.1: ethanol / 48 h / 80 °C

4.1: trifluoroacetic acid / 16 h

5.1: hexamethyldistannane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

5.2: 16 h / 100 °C / Inert atmosphere

With chlorosulfonic acid; hexamethyldistannane; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272355-01-7
2-methyl-6-(5-phenyl-4-(pyridine-2-ylmethylamino)quinazolin-2-yl)imidazo[1,2-a]pyridine-8-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

4.1: hexamethyldistannane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 16 h / 100 °C / Inert atmosphere

With hexamethyldistannane; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;